Household transmissibility and other characteristics of seasonal oseltamivir-resistant influenza A(H1N1) viruses, Germany, 2007-8.
Identifieur interne : 000349 ( Main/Exploration ); précédent : 000348; suivant : 000350Household transmissibility and other characteristics of seasonal oseltamivir-resistant influenza A(H1N1) viruses, Germany, 2007-8.
Auteurs : U. Buchholz [Allemagne] ; S. Brockmann ; S. Duwe ; B. Schweiger ; M. An Der Heiden ; B. Reinhardt ; S. BudaSource :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [ 1560-7917 ] ; 2010.
Descripteurs français
- KwdFr :
- Allemagne (épidémiologie), Antiviraux (usage thérapeutique), Appréciation des risques (MeSH), Facteurs de risque (MeSH), Femelle (MeSH), Grippe humaine (traitement médicamenteux), Grippe humaine (transmission), Grippe humaine (épidémiologie), Humains (MeSH), Incidence (MeSH), Logement (statistiques et données numériques), Mâle (MeSH), Oséltamivir (usage thérapeutique), Résistance virale aux médicaments (MeSH), Saisons (MeSH), Sous-type H1N1 du virus de la grippe A (MeSH), Épidémies de maladies (statistiques et données numériques), Études de cohortes (MeSH).
- MESH :
- statistiques et données numériques : Logement, Épidémies de maladies.
- traitement médicamenteux : Grippe humaine.
- usage thérapeutique : Antiviraux, Grippe humaine, Oséltamivir.
- épidémiologie : Allemagne, Grippe humaine.
- Appréciation des risques, Facteurs de risque, Femelle, Humains, Incidence, Mâle, Résistance virale aux médicaments, Saisons, Sous-type H1N1 du virus de la grippe A, Études de cohortes.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Antiviral Agents (therapeutic use), Cohort Studies (MeSH), Disease Outbreaks (statistics & numerical data), Drug Resistance, Viral (MeSH), Female (MeSH), Germany (epidemiology), Housing (statistics & numerical data), Humans (MeSH), Incidence (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (drug therapy), Influenza, Human (epidemiology), Influenza, Human (transmission), Male (MeSH), Oseltamivir (therapeutic use), Risk Assessment (MeSH), Risk Factors (MeSH), Seasons (MeSH).
- MESH :
- chemical , therapeutic use : Antiviral Agents, Oseltamivir.
- geographic , epidemiology : Germany.
- drug therapy : Influenza, Human.
- epidemiology : Influenza, Human.
- statistics & numerical data : Disease Outbreaks, Housing.
- transmission : Influenza, Human.
- Cohort Studies, Drug Resistance, Viral, Female, Humans, Incidence, Influenza A Virus, H1N1 Subtype, Male, Risk Assessment, Risk Factors, Seasons.
Abstract
During the influenza season 2007-8, the proportion of seasonal influenza A(H1N1) viruses resistant to the neuraminidase inhibitor oseltamivir increased worldwide. We conducted an investigation to compare patients infected with oseltamivir-resistant (ose-R) and oseltamivir- susceptible (ose-S) influenza A(H1N1) viruses regarding risk factors for resistance and the capability to transmit in the household setting. Within a cohort of 396 laboratory confirmed influenza patients from sentinel physicians we conducted a nested case-control study among patients infected with A(H1N1). Thirty patients in the cohort were infected with influenza B, none with influenza A(H3N2) and 366 with A(H1N1). Of the 366 A(H1N1) viruses 52 (14%) were ose-R. Demographic characteristics, oseltamivir exposure, travel history and outcome were not significantly different between ose-S and ose-R patients. Among 133 households in the nested case-control study, secondary household attack rates in households with ose-R cases and households with ose-S cases were similar (23 versus 26%; p-value=0.54). Ose-R household status and occurrence of secondary cases were associated with an odds ratio of 0.85 (95% confidence interval 0.38-1.88). We conclude that seasonal ose-R influenza A(H1N1) viruses have transmitted well in the household setting.
PubMed: 20158979
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Household transmissibility and other characteristics of seasonal oseltamivir-resistant influenza A(H1N1) viruses, Germany, 2007-8.</title><author><name sortKey="Buchholz, U" sort="Buchholz, U" uniqKey="Buchholz U" first="U" last="Buchholz">U. Buchholz</name><affiliation wicri:level="3"><nlm:affiliation>Robert Koch Institute, Berlin, Germany. BuchholzU@rki.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Robert Koch Institute, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Brockmann, S" sort="Brockmann, S" uniqKey="Brockmann S" first="S" last="Brockmann">S. Brockmann</name></author><author><name sortKey="Duwe, S" sort="Duwe, S" uniqKey="Duwe S" first="S" last="Duwe">S. Duwe</name></author><author><name sortKey="Schweiger, B" sort="Schweiger, B" uniqKey="Schweiger B" first="B" last="Schweiger">B. Schweiger</name></author><author><name sortKey="An Der Heiden, M" sort="An Der Heiden, M" uniqKey="An Der Heiden M" first="M" last="An Der Heiden">M. An Der Heiden</name></author><author><name sortKey="Reinhardt, B" sort="Reinhardt, B" uniqKey="Reinhardt B" first="B" last="Reinhardt">B. Reinhardt</name></author><author><name sortKey="Buda, S" sort="Buda, S" uniqKey="Buda S" first="S" last="Buda">S. Buda</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20158979</idno><idno type="pmid">20158979</idno><idno type="wicri:Area/Main/Corpus">000348</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000348</idno><idno type="wicri:Area/Main/Curation">000348</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000348</idno><idno type="wicri:Area/Main/Exploration">000348</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Household transmissibility and other characteristics of seasonal oseltamivir-resistant influenza A(H1N1) viruses, Germany, 2007-8.</title><author><name sortKey="Buchholz, U" sort="Buchholz, U" uniqKey="Buchholz U" first="U" last="Buchholz">U. Buchholz</name><affiliation wicri:level="3"><nlm:affiliation>Robert Koch Institute, Berlin, Germany. BuchholzU@rki.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Robert Koch Institute, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Brockmann, S" sort="Brockmann, S" uniqKey="Brockmann S" first="S" last="Brockmann">S. Brockmann</name></author><author><name sortKey="Duwe, S" sort="Duwe, S" uniqKey="Duwe S" first="S" last="Duwe">S. Duwe</name></author><author><name sortKey="Schweiger, B" sort="Schweiger, B" uniqKey="Schweiger B" first="B" last="Schweiger">B. Schweiger</name></author><author><name sortKey="An Der Heiden, M" sort="An Der Heiden, M" uniqKey="An Der Heiden M" first="M" last="An Der Heiden">M. An Der Heiden</name></author><author><name sortKey="Reinhardt, B" sort="Reinhardt, B" uniqKey="Reinhardt B" first="B" last="Reinhardt">B. Reinhardt</name></author><author><name sortKey="Buda, S" sort="Buda, S" uniqKey="Buda S" first="S" last="Buda">S. Buda</name></author></analytic><series><title level="j">Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</title><idno type="eISSN">1560-7917</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (therapeutic use)</term><term>Cohort Studies (MeSH)</term><term>Disease Outbreaks (statistics & numerical data)</term><term>Drug Resistance, Viral (MeSH)</term><term>Female (MeSH)</term><term>Germany (epidemiology)</term><term>Housing (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Incidence (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (MeSH)</term><term>Influenza, Human (drug therapy)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (transmission)</term><term>Male (MeSH)</term><term>Oseltamivir (therapeutic use)</term><term>Risk Assessment (MeSH)</term><term>Risk Factors (MeSH)</term><term>Seasons (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allemagne (épidémiologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Appréciation des risques (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (traitement médicamenteux)</term><term>Grippe humaine (transmission)</term><term>Grippe humaine (épidémiologie)</term><term>Humains (MeSH)</term><term>Incidence (MeSH)</term><term>Logement (statistiques et données numériques)</term><term>Mâle (MeSH)</term><term>Oséltamivir (usage thérapeutique)</term><term>Résistance virale aux médicaments (MeSH)</term><term>Saisons (MeSH)</term><term>Sous-type H1N1 du virus de la grippe A (MeSH)</term><term>Épidémies de maladies (statistiques et données numériques)</term><term>Études de cohortes (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Disease Outbreaks</term><term>Housing</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Logement</term><term>Épidémies de maladies</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Grippe humaine</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cohort Studies</term><term>Drug Resistance, Viral</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Influenza A Virus, H1N1 Subtype</term><term>Male</term><term>Risk Assessment</term><term>Risk Factors</term><term>Seasons</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Appréciation des risques</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Incidence</term><term>Mâle</term><term>Résistance virale aux médicaments</term><term>Saisons</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Études de cohortes</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the influenza season 2007-8, the proportion of seasonal influenza A(H1N1) viruses resistant to the neuraminidase inhibitor oseltamivir increased worldwide. We conducted an investigation to compare patients infected with oseltamivir-resistant (ose-R) and oseltamivir- susceptible (ose-S) influenza A(H1N1) viruses regarding risk factors for resistance and the capability to transmit in the household setting. Within a cohort of 396 laboratory confirmed influenza patients from sentinel physicians we conducted a nested case-control study among patients infected with A(H1N1). Thirty patients in the cohort were infected with influenza B, none with influenza A(H3N2) and 366 with A(H1N1). Of the 366 A(H1N1) viruses 52 (14%) were ose-R. Demographic characteristics, oseltamivir exposure, travel history and outcome were not significantly different between ose-S and ose-R patients. Among 133 households in the nested case-control study, secondary household attack rates in households with ose-R cases and households with ose-S cases were similar (23 versus 26%; p-value=0.54). Ose-R household status and occurrence of secondary cases were associated with an odds ratio of 0.85 (95% confidence interval 0.38-1.88). We conclude that seasonal ose-R influenza A(H1N1) viruses have transmitted well in the household setting.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20158979</PMID><DateCompleted><Year>2010</Year><Month>05</Month><Day>17</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1560-7917</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>6</Issue><PubDate><Year>2010</Year><Month>Feb</Month><Day>11</Day></PubDate></JournalIssue><Title>Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</Title><ISOAbbreviation>Euro Surveill.</ISOAbbreviation></Journal><ArticleTitle>Household transmissibility and other characteristics of seasonal oseltamivir-resistant influenza A(H1N1) viruses, Germany, 2007-8.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">19483</ELocationID><Abstract><AbstractText>During the influenza season 2007-8, the proportion of seasonal influenza A(H1N1) viruses resistant to the neuraminidase inhibitor oseltamivir increased worldwide. We conducted an investigation to compare patients infected with oseltamivir-resistant (ose-R) and oseltamivir- susceptible (ose-S) influenza A(H1N1) viruses regarding risk factors for resistance and the capability to transmit in the household setting. Within a cohort of 396 laboratory confirmed influenza patients from sentinel physicians we conducted a nested case-control study among patients infected with A(H1N1). Thirty patients in the cohort were infected with influenza B, none with influenza A(H3N2) and 366 with A(H1N1). Of the 366 A(H1N1) viruses 52 (14%) were ose-R. Demographic characteristics, oseltamivir exposure, travel history and outcome were not significantly different between ose-S and ose-R patients. Among 133 households in the nested case-control study, secondary household attack rates in households with ose-R cases and households with ose-S cases were similar (23 versus 26%; p-value=0.54). Ose-R household status and occurrence of secondary cases were associated with an odds ratio of 0.85 (95% confidence interval 0.38-1.88). We conclude that seasonal ose-R influenza A(H1N1) viruses have transmitted well in the household setting.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Buchholz</LastName><ForeName>U</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Robert Koch Institute, Berlin, Germany. BuchholzU@rki.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brockmann</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Duwe</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Schweiger</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>an der Heiden</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Reinhardt</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Buda</LastName><ForeName>S</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>02</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Sweden</Country><MedlineTA>Euro Surveill</MedlineTA><NlmUniqueID>100887452</NlmUniqueID><ISSNLinking>1025-496X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>20O93L6F9H</RegistryNumber><NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024882" MajorTopicYN="N">Drug Resistance, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006798" MajorTopicYN="N">Housing</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000635" MajorTopicYN="Y">transmission</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012621" MajorTopicYN="Y">Seasons</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>2</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>2</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20158979</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><noCountry><name sortKey="An Der Heiden, M" sort="An Der Heiden, M" uniqKey="An Der Heiden M" first="M" last="An Der Heiden">M. An Der Heiden</name><name sortKey="Brockmann, S" sort="Brockmann, S" uniqKey="Brockmann S" first="S" last="Brockmann">S. Brockmann</name><name sortKey="Buda, S" sort="Buda, S" uniqKey="Buda S" first="S" last="Buda">S. Buda</name><name sortKey="Duwe, S" sort="Duwe, S" uniqKey="Duwe S" first="S" last="Duwe">S. Duwe</name><name sortKey="Reinhardt, B" sort="Reinhardt, B" uniqKey="Reinhardt B" first="B" last="Reinhardt">B. Reinhardt</name><name sortKey="Schweiger, B" sort="Schweiger, B" uniqKey="Schweiger B" first="B" last="Schweiger">B. Schweiger</name></noCountry><country name="Allemagne"><region name="Berlin"><name sortKey="Buchholz, U" sort="Buchholz, U" uniqKey="Buchholz U" first="U" last="Buchholz">U. Buchholz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeAllemagneV4/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000349 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000349 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= GrippeAllemagneV4
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:20158979
|texte= Household transmissibility and other characteristics of seasonal oseltamivir-resistant influenza A(H1N1) viruses, Germany, 2007-8.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20158979" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeAllemagneV4
| This area was generated with Dilib version V0.6.35. |  |